Evidence map›Paper›PMID 41246408›Full record

ArticleOpen veterinary journal2025

Therapeutic efficacy of liposomal caffeic acid in high-fat diet-induced obesity in rats: Targeting hedgehog signalling pathway, adipokines, and insulin resistance.

Wafa S Alansari, Mahran Mohamed Abd El-Emam, Rawan Altalhi, Safaa I Khater, Tarek Khamis, Hoda S Sherkawy, Abdelhamid M Fares, Marwa M Lotfy, Ola Mohammed Youssef, Engy Mohamed Mohamed Yassin

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Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wafa S AlansariBiochemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
Mahran Mohamed Abd El-EmamDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Rawan AltalhiDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Safaa I KhaterDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Tarek KhamisDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Hoda S SherkawyMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Abdelhamid M FaresDepartment of Pathology, Faculty of Veterinary Medicine, University of Sadat City, Monofiya, Egypt.
Marwa M LotfyDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Ola Mohammed YoussefDepartment of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Engy Mohamed Mohamed YassinDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity spurred by a high-fat diet (HFD) has emerged as a significant worldwide health issue. Caffeic acid (CA) is a plant-derived phenolic compound found in various foods such as coffee, wine, and tea. It exhibits antioxidant, anti-inflammatory, and anticarcinogenic properties. However, the therapeutic potential of this substance is hindered by its poor water solubility and low oral bioavailability. Aim: In this study, CA was loaded into liposomes Caffeic Acid -Loaded Liposomes (CA-Lip) , and the potential role of CA-Lip in mitigating HFD-induced obesity in rats was examined. Methods: Forty male Wistar rats were used in this investigation. They were allocated into four groups: the first was fed a regular diet; the second received a normal diet plus CA-Lip; the third received an HFD; and the fourth received both an HFD and CA-Lip. Results: The developed CA-Lip showed a particle size of 125 nm, zeta potential of -15 mV, and entrapment efficiency of 82%. The HFD+CA-Lip group's body weight was considerably lower than that of the HFD group. The HFD+CA-Lip group also showed a significant improvement in their serum lipid profiles. CA-Lip lowered levels of adipokines, which encourage inflammation, including leptin, interleukin-6, and tumor necrosis factor-α. It also reduced the size of the adipocytes when compared to the HFD control group. Furthermore, it reversed the HFD-induced upregulation of Hh genes [protein patched homolog 1 (PTCH1), Hh-interacting protein (HHIP), glioma-associated oncogene homolog 1 (Gli1), and smoothened (Smo) receptor] in adipose tissue. Conclusion: In summary, CA-Lip may reduce obesity and related inflammation by activating the Hh signaling pathway.

Indexed as

AdipokinesCaffeic AcidsHedgehog ProteinsInsulin ResistanceObesityAnimalsDiet, High-FatLiposomesMaleRatsRats, WistarSignal TransductionAdipokinescaffeic acidCaffeic AcidsHedgehog ProteinsLiposomesAdipokinesCaffeic acidHhog pathwayLipidLiposomesObesity

Identifiers

PMID41246408
PMCPMC12613224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.