Evidence map›Paper›PMID 41246670›Full record

ReviewCureus2025

Natural Silica and Plant-Derived Fillers for Dental Composite Resins: A Narrative Review.

Guanlin Gao, Raja Azman Raja Awang, Wan Muhamad Amir W Ahmad, Noor Huda Ismail

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guanlin GaoSchool of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MYS.
Raja Azman Raja AwangSchool of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MYS.
Wan Muhamad Amir W AhmadSchool of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MYS.
Noor Huda IsmailSchool of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MYS.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing limitations in antibacterial performance, biocompatibility, and environmental sustainability of traditional dental composite resin fillers have caused urgent issues such as secondary caries and marginal microleakage that require immediate attention. The emergence of natural fillers as sustainable options is significant due to their unique bioactive properties and environmental friendliness. This review systematically retrieved and analysed relevant literature published between 2015 and June 2025, focusing on the application mechanisms, performance characteristics, and clinical translation potential of natural silica and plant-derived fillers in dental composite resins. Natural silica derived from agricultural waste, such as rice husks, not only enables high-value utilisation of biomass resources but also improves the mechanical properties of composite resins. Plant-based fillers, like miswak, offer multiple functions, including antibacterial and anti-inflammatory effects, due to their rich bioactive components. However, challenges such as the release behaviour of bioactive components over time, interface bonding stability, and batch consistency remain obstacles to clinical use. While natural fillers show great promise in dental composite resins, further research is clearly necessary. The potential of surface modification techniques, optimisation of composite formulations, and standardised preparation methods is substantial, and detailed studies can help ensure successful translation from the laboratory to clinical practice.

Indexed as

dental composite resinsmiswaknatural silicaplant-derived fillersrice husk

Identifiers

PMID41246670
PMCPMC12611795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.