Evidence map›Paper›PMID 41246694›Full record

ReviewCureus2025

Neurocognitive and Neurological Effects of Coffee and Caffeine: A Narrative Review.

Joseph V Pergolizzi, Julius T Tenenbaum, Claudio Pergolizzi, Jo Ann K LeQuang

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph V PergolizziExecutive Department, NEMA Research, Inc., Naples, USA.
Julius T TenenbaumPain Management Department, NEMA Research, Inc., Naples, USA.
Claudio PergolizziScientific Operations Department, NEMA Research, Inc., Naples, USA.
Jo Ann K LeQuangScientific Communications Department, NEMA Research, Inc., Naples, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coffee, a popular beverage, is surprisingly complex and increasingly studied for its potential health benefits. In particular, coffee contains caffeine, which may play a role in alertness, cognition, and memory. Coffee also contains an abundance of polyphenols and other compounds, which may confer specific health benefits. It is well known that coffee drinking can ward off drowsiness and fatigue, but the mechanisms behind this are not clearly understood. The caffeine in coffee can inhibit adenosine, but this mechanism is not well understood. Whether or not coffee has protective effects against neurodegenerative conditions is being actively studied. Coffee may confer significant neuroprotective, anti-inflammatory, and cognitive benefits, which are of particular interest in aging populations and warrant greater study. A challenge in studying coffee's neurocognitive aspects is that there are multiple types of coffee, and "dosing," or how much coffee is consumed over time, can vary widely among studies.

Indexed as

adenosine antagonismalzheimer's diseasecaffeinecoffeecognitive improvementneuroprotectionparkinson's diseasepolyphenols

Identifiers

PMID41246694
PMCPMC12619674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.