ArticleCureus2025
Antioxidative Activity of Remimazolam as a Direct Free Radical Scavenger in Comparison With Midazolam.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Advances in basic research on post-cardiac arrest syndrome in adults: a comprehensive review.Frontiers in medicine · 2026Review
- Article
- [Remimazolam stabilizes hemodynamics during anesthesia induction but fails to reduce renal injury risk following laparoscopic partial nephrectomy: a propensity score-matched retrospective cohort study].Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Remimazolam, a novel ultra-short-acting benzodiazepine, has seen increasing use in recent years as a general anesthetic for patients with poor cardiac function and older adults due to its hemodynamic stability and rapid recovery profile. Alternatively, it has also become clear through several basic and clinical studies that it suppresses inflammation and oxidative stress. However, its direct free-radical-scavenging activity remains largely unreported. In this study, we aimed to evaluate its direct non-enzymatic scavenging activity against multiple free radical species. Materials and methods A constant amount of eight types of free radicals or singlet oxygen, a reactive oxygen species, was generated in disposable cells. After adding various concentrations of remimazolam to the free radical generation system, the radical scavenging activity of the drug was measured using electron spin resonance spectroscopy with the spin-trapping method. Concentration-response curves for the scavenging activity against free radicals and singlet oxygen were constructed. The 50% inhibitory concentration (IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.