Is CepA from

Abstract read

In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Le Phung HienCollege of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.ORCID 0000-0002-5675-152X

Melissa H BrownCollege of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.ORCID 0000-0001-6461-7550

Funding

National Health and Medical Research Council 2020421

6 · The paper itself

Abstract

Amid the antibiotic resistance crisis, biocides, including antiseptics and disinfectants, are indispensable tools to limit the spread of nosocomial infections and extensively drug-resistant bacteria. Thus, it is crucial that they remain effective. Extruding biocides from the cell using efflux systems is one mechanism by which bacteria can survive in their presence. The CepA protein from IMPORTANCE: Understanding the structure and function of efflux pumps is crucial for addressing efflux-mediated resistance. Transporters that pump out biocides or heavy metals are not uncommon. However, to date, no transport protein capable of extruding both types of substrates has been reported. Initially, it was proposed that

Indexed as

Bacterial ProteinsDisinfectantsKlebsiella pneumoniaeMembrane Transport ProteinsMetals, HeavyBiological TransportChlorhexidineDrug Resistance, BacterialEscherichia coliMicrobial Sensitivity TestsBacterial ProteinsChlorhexidineDisinfectantsMembrane Transport ProteinsMetals, Heavyantimicrobial resistancebiocideCepAefflux pumpheavy metalKlebsiella pneumoniae

Identifiers

PMID41247035

DOI10.1128/msphere.00512-25

PMCPMC12724285

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.