ArticlePsychiatry and clinical psychopharmacology2025
Efficacy of Eszopiclone Plus Acupuncture Therapy by Dispersing the Stagnated Liver-Qi and Regulating the Spirit for Treating Chronic Fatigue Syndrome-Related Sleep Disorders.
Article in Psychiatry and clinical psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To analyze the overall response of eszopiclone plus acupuncture therapy by dispersing the stagnated liver-qi and regulating the spirit (the acupuncture therapy) for treating chronic fatigue syndrome (CFS)-related sleep disorders. Methods: A retrospective analysis was conducted on 107 patients with CFS-induced sleep disorders treated at the Hainan Provincial People's Hospital from February 2021 to February 2023. Among these, 50 patients who received eszopiclone tablets were collected as the control group. The remaining 57 patients who received the acupuncture therapy in addition to the treatment in the control group were collected as the observation group. The Pittsburgh Sleep Quality Index (PSQI) was adopted for evaluating sleep quality before and after treatment in both groups. Clinical overall response rate was compared between the 2 groups. An enzyme-linked immunosorbent assay was conducted for measuring fasting serum levels of 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) prior to and post treatment. Adverse reactions in both groups were also recorded. Results: The observation group got significantly lower PSQI scores than the control group (P < .05). The overall response rate of the observation group seemed to be higher than that of the control group (P=.063). The observation group showed significantly higher post-treatment 5-HT and BDNF levels than the control group (both P < .05). Safety profiles favored the observation group, with fewer adverse reactions reported (7.02% vs 22.00%) (P=.026). Conclusion: Eszopiclone plus the acupuncture therapy enhances the efficacy of treating CFS-induced sleep disorders, effectively improves serum 5-HT and BDNF levels in patients, and reduces adverse reactions.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.