Evidence map›Paper›PMID 41247465›Full record

Observational studySurgery today2026

Preoperative brain natriuretic peptide levels are associated with postoperative all-cause mortality in patients with lung cancer.

Shinya Otsuka, Haruhiko Shiiya, Ryo Takagi, Kazufumi Okada, Akihiro Sasaki, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Hideki Ujiie, Masato Aragaki, Tatsuya Kato

Abstract readObservational Study
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In one paragraph

Observational study in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shinya OtsukaDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.ORCID http://orcid.org/0000-0002-2489-9992
Haruhiko ShiiyaDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.ORCID http://orcid.org/0000-0003-1766-7736
Ryo TakagiData Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.ORCID http://orcid.org/0000-0002-5930-0329
Kazufumi OkadaData Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Akihiro SasakiDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Kazuto OhtakaDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.
Aki Fujiwara-KurodaDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.ORCID http://orcid.org/0000-0002-6231-4844
Hideki UjiieDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.ORCID http://orcid.org/0000-0001-6119-8776
Masato AragakiDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan.ORCID http://orcid.org/0000-0002-2943-764X
Tatsuya KatoDepartment of Thoracic Surgery, Graduate School of Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-Ku, Sapporo, Hokkaido, 060-8648, Japan. katotatu7@msn.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSerum levels of cardiovascular markers, including brain natriuretic peptide (BNP), are associated with the prognosis of cancer patients. This study examined the relationship between the preoperative blood BNP level and the long-term prognosis after curative lung cancer resection.

methodsPatients who underwent radical resection for lung cancer at our institution between January 2012 and June 2019 were divided into the high- (≥ 18.5 pg/ml) and low- (< 18.5 pg/ml) BNP groups. Kaplan-Meier curves were used to analyze the postoperative overall survival (OS) and relapse-free survival (RFS). The cumulative incidence function (CIF) was analyzed using the Gray's test. Univariate and multivariate Cox proportional hazards models were used to identify independent predictors of the OS.

resultsThe postoperative OS was significantly worse in the high-BNP group than in the low-BNP group (p = 0.03), but there was no statistically significant difference in the RFS (p = 0.09). A CIF analysis indicated that non-cancer-related deaths had a greater impact on the RFS than cancer recurrence. Blood BNP levels possibly affected the OS independently (hazard ratio, 1.50).

conclusionsPreoperative BNP levels in patients with lung cancer may indicate a potentially compromised condition and can be associated with the postoperative OS. However, the link between the BNP level and lung cancer severity remains unclear.

Indexed as

Lung NeoplasmsNatriuretic Peptide, BrainPneumonectomyAgedBiomarkersCause of DeathFemaleHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedPostoperative PeriodPredictive Value of TestsPreoperative PeriodPrognosisBiomarkersNatriuretic Peptide, BrainBrain natriuretic peptidesLung cancerOverall survivalRadical resection

Identifiers

PMID41247465

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.