Evidence map›Paper›PMID 41247497›Full record

Trial reportIntensive care medicine2025

Comparison of two different bicarbonate replacement fluids during CVVH with RCA: a prospective, randomized, controlled trial.

Fabian Perschinka, Paul Köglberger, Andrea Köhler, Georg Franz Lehner, Andreas Peer, Sarah Maier, Hanno Ulmer, Romuald Bellmann, Lui G Forni, Michael Joannidis

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071171 (Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation - A Prospective, Randomized, Controlled, Open, Cross-over, Phase II, Single-center Pilot Study [BiPhox-Trial]), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071171 phase2completednot on this map

Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation - A Prospective, Randomized, Controlled, Open, Cross-over, Phase II, Single-center Pilot Study [BiPhox-Trial]

TypeinterventionalSponsorMedical University InnsbruckRan2020 to 2024Enrolled88ConditionsCritically Ill, Acute Kidney Injury, Renal Replacement Therapy, Continuous Renal Replacement TherapyArmsCVVH with Phoxilium® in the first 48h after randomization, CVVH with Biphozyl® in the first 48h after randomization, CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®), CVVH with Biphozyl® in the second 48h after randomization (after previous 48h with Phoxilium®)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabian Perschinka *Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.ORCID 0000-0003-0677-8756
Paul Köglberger *Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.ORCID 0000-0002-1772-5214
Andrea KöhlerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Georg Franz LehnerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Andreas PeerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Sarah MaierInstitute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University Innsbruck, Innsbruck, Austria.ORCID 0000-0002-7012-3669
Hanno UlmerInstitute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University Innsbruck, Innsbruck, Austria.ORCID 0000-0001-5911-1002
Romuald BellmannDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.ORCID 0000-0003-2861-3258
Lui G ForniCritical Care Unit, Royal Surrey Hospital, Guildford, UK.ORCID 0000-0002-0617-5309
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria. michael.joannidis@i-med.ac.at.ORCID 0000-0002-6996-0881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to compare a high (HBF) and low (LBF) bicarbonate (HCO

methodsIn this prospective, randomized, controlled, open-label, cross-over, single-center trial, patients were randomized to initially receive either LBF (22 mmol/l HCO

resultsA total of 88 patients were included. The rates for at least one pH and HCO

conclusionLBF showed significantly lower rates of pH and HCO CLINICALTRIALS: GOV-IDENTIFIER: NCT04071171.

Indexed as

BicarbonatesAcid-Base EquilibriumAgedCross-Over StudiesFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedProspective StudiesBicarbonatesAcid–base profileAcute kidney injuryContinuous veno-venous hemofiltrationRenal replacement therapyReplacement fluids

Identifiers

PMID41247497
PMCPMC12678463

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.