Evidence map›Paper›PMID 41247552›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Combined Use of Aqueous Extracts and Polysaccharides from Angelica sinensis and Platycladus orientalis Treats Androgenetic Alopecia.

Donglin Sui, Shugang Li, Yixuan Li, Shouhao Zhao, Huan Li, Chunqing Ai, Hong Chang, Xiaomeng Ren

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Donglin SuiState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Shugang LiState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Yixuan LiState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Shouhao ZhaoState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Huan LiState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Chunqing AiState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Hong ChangState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China.
Xiaomeng RenState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, 1 Qinggongyuan Road, Dalian, Liaoning, 116034, China. rxmfighting@163.com.

Funding

the Special Fund for Basic scientific research in universities under the auspices of Liaoning Province LJ212410152058
6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is a widely prevalent condition that significantly impacts both physical well-being and psychological health. Conventional treatments are often accompanied by considerable side effects and demonstrate variable efficacy. This study explores the therapeutic potential of polysaccharides derived from Angelica sinensis (ASP) and Platycladus orientalis (POP), alongside their respective aqueous extracts, employing a dual approach that combines oral administration of polysaccharides with topical application. Notably, these polysaccharides and their aqueous extracts effectively attenuate follicular miniaturization and chronic inflammation, while simultaneously promoting the expression of CD31 and Ki67 proteins, thereby enhancing angiogenesis and follicular development. Furthermore, they reactivate the Wnt/β-catenin signaling pathway and inhibit androgen receptors (AR), resulting in a significant stimulation of hair regrowth. Cumulatively, the polysaccharides and their aqueous extracts indicate a promising approach for mitigating hair loss and inflammation linked to AGA, offering preliminary evidence for a novel therapeutic intervention in AGA that warrants further investigation.

Indexed as

AlopeciaAngelica sinensisPlant ExtractsPolysaccharidesAdministration, OralAnimalsHair FollicleHumansMaleMiceReceptors, AndrogenWnt Signaling PathwayPlant ExtractsPolysaccharidesReceptors, AndrogenAndrogenetic alopeciaAngelica sinensis polysaccharideAqueous extractsPlatycladus orientalis polysaccharide

Identifiers

PMID41247552

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.