ArticleAmerican journal of physiology. Endocrinology and metabolism2025
Assessing the rate dependence of the first phase of glucose-stimulated insulin secretion: dynamic perifusion studies with isolated human pancreatic islets.
Article in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effect of Immunosuppressive Drugs on Glucose-Stimulated Insulin Secretion: Concentration-Response Studies in Dynamic Perifusion Assays.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial development and remodeling occur at pancreatic progenitor stage during induction of stem cell-derived islet organoids.Frontiers in endocrinology · 2026Article
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4 authors.
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Abstract
Insulin released in response to a stepwise increase in glucose (square wave) is biphasic with a transient 5-10 min first-phase peak and a more sustained second phase. Although the first phase is generally assumed to be rate-dependent and the second concentration-dependent, detailed studies of first-phase rate sensitivity are lacking. We performed dynamic perifusion studies with human islets using customizable glucose ramps and established the corresponding insulin secretion time profiles. First-phase release was defined as the excess insulin above that expected from the concentration-dependent second phase, and its dependence on the glucose gradient (rate of increase) was examined. The first-phase insulin release rate calculated this way increased with the gradient and fit well to a Hill-type sigmoid function with a half-maximal value around 1.25 mM/min (
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