Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope-specific immune response.

Jordan T VanderBurgt, Richard Strasser, Hong Zhu, Angelo Kaldis, Christopher P Garnham, Rima Menassa

Abstract read

In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan T VanderBurgtLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, Canada.ORCID 0009-0009-9889-1705

Richard StrasserDepartment of Biotechnology and Food Sciences, BOKU University, Vienna, Austria.

Hong ZhuLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, Canada.

Angelo KaldisLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, Canada.

Christopher P GarnhamLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, Canada.ORCID 0000-0002-1035-6970

Rima MenassaLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, Canada.ORCID 0000-0003-3536-0332

Funding

Agriculture and Agri-Food Canada J-003053

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is one of the major diseases affecting the global swine industry. Current methods to control this viral disease are insufficient or pose safety concerns; therefore, there is a need for a safer and more effective vaccine against PRRS. In this study, we designed a chimeric nanoparticle vaccine through genetic fusion of an epitope composed of portions from two PRRS viral proteins, M and GP5, with lumazine synthase from Aquifex aeolicus. Transient expression in the leaves of Nicotiana benthamiana plants resulted in soluble levels around 0.18 mg·g

Indexed as

Antigens, ViralEpitopesNanoparticlesPorcine Reproductive and Respiratory SyndromeViral VaccinesAnimalsAntibodies, ViralMiceMice, Inbred BALB CMultienzyme ComplexesNicotianaPlant LeavesPlants, Genetically ModifiedPorcine respiratory and reproductive syndrome virusRecombinant Fusion ProteinsSwine6,7-dimethyl-8-ribityllumazine synthaseAntibodies, ViralAntigens, ViralEpitopesMultienzyme ComplexesRecombinant Fusion ProteinsViral Vaccineslumazine synthaseplant molecular farmingprotein nanoparticlePRRSsubunit vaccine

Identifiers

PMID41247829

DOI10.1111/febs.70288

PMCPMC13044993

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.