Evidence map›Paper›PMID 41248220›Full record

ArticleCirculation2025

A Novel miniALPK3 Gene Therapy for ALPK3-Associated Cardiomyopathy.

Wei Feng, Julijus Bogomolovas, Abraham Grant Shain, Li Wang, Chao Chen, Mao Ye, Yusu Gu, Xiaohai Zhou, Ju Chen

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei FengDepartment of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0002-9106-4258
Julijus BogomolovasDepartment of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0001-8344-1909
Abraham Grant ShainDepartment of Medicine, University of California San Diego, La Jolla, CA.
Li WangDepartment of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0002-6586-2571
Chao ChenDepartment of Medicine, University of California San Diego, La Jolla, CA.
Mao YeDepartment of Medicine, University of California San Diego, La Jolla, CA.
Yusu GuDepartment of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0002-9543-8472
Xiaohai ZhouDepartment of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0002-0987-0374
Ju ChenDepartment of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0001-7674-4776

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
ATF4 a Novel Regulator of Cardiac DevelopmentR01HL164549 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen · 2023 to 2026
$2.2M
Molecular basis of ASNA1 cardiomyopathyR01HL170002 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen · 2024 to 2026
$1.6M
Gene Therapy for ALPK3 Cardiomyopathy Using MiniALPK3R01HL175344 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen · 2024 to 2026
$1.6M
NHLBI NIH HHS R01 HL164549NHLBI NIH HHS R01 HL170002NHLBI NIH HHS R01 HL175344NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adeno-associated virusALPK3cardiomyopathyCRISPR/Cas9gene therapy

Identifiers

PMID41248220
PMCPMC12626394

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.