ArticleBMJ open2025
Progression in adult patients with early-stage chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania: prospective longitudinal study.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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2 authors.
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Abstract
objectiveTo determine progression in adult patients with early-stage chronic kidney disease (CKD) attending tertiary hospitals in Dodoma, Tanzania.
designProspective longitudinal study.
settingThis study was conducted in two tertiary hospitals in Dodoma, Tanzania.
participantsThe population in this study was adult patients aged ≥18 years with early-stage CKD who were attending nephrology and medical outpatient clinics at Benjamin Mkapa Hospital and Dodoma Regional Referral Hospital, which are tertiary hospitals in Dodoma, Tanzania, from November 2020 to March 2022. Inclusion criteria included: patients aged ≥18 years of age, attending the clinic for at least 3 months with baseline clinical data on their files, estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m MAIN OUTCOME: The dependent variable in this study was CKD progression, which was assessed after 12 months of follow-up.
resultsA total of 352 participants with a median age of 54 (47-59) years were enrolled; the prevalence of progression of early-stage CKD was 28.0% (97/346). For patients with CKD progression, the baseline median eGFR was 43 (41-49) mL/min/1.73 m
conclusionA substantial portion of adult patients with early-stage CKD were found to have progression after 12 months of follow-up. Diabetes mellitus, proteinuria, anaemia and use of local herbal medicines were significant predictors for CKD progression. Of the patients with CKD progression, more than half of the patients were found to have LVH, almost one third of the patients had evidence of CAD on non-invasive testing, and few patients died.
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