Evidence map›Paper›PMID 41248480›Full record

ArticleExperimental physiology2026

Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries.

Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I Aldana, Hirotsugu Tsuchimochi, Mark T Waddingham, Kristine Freude and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gry Freja SkovstedDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.
Alex AupetitDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.
Karl BjörlingDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.
Kristian Agmund HaanesTranslational Research Centre, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.
Susanne SybergTranslational Research Centre, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.
Niklas Rye JørgensenTranslational Research Centre, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.
Blanca I AldanaDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.
Hirotsugu TsuchimochiDepartment of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Mark T WaddinghamDepartment of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Kristine FreudeDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.
James Todd PearsonDepartment of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0002-3318-5406
Lars Jørn JensenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark.ORCID https://orcid.org/0000-0003-4559-7456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G-protein-coupled receptors and G

Indexed as

AgingLysophospholipidsMesenteric ArteriesMuscle Tonusrho-Associated KinasesSphingosineAnimalsCerebral ArteriesMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularSignal TransductionVasoconstrictionLysophospholipidsrho-Associated KinasesSphingosinesphingosine 1-phosphateageingG‐protein coupled receptorsmyogenic toneresistance arteriesRho‐kinaseS1P‐signalling

Identifiers

PMID41248480
PMCPMC12949166

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.