Evidence map›Paper›PMID 41248785›Full record

ArticleBiological psychology2025

Child and adolescent internalizing and externalizing traits, and epigenetic summary scores: A scoping review.

Erin B Ware, Joshua A Goode, Uma N Hornish, Devin P McNulty, Thomas Karadimas, Gillian Acedo, Jaedyn Birchmier, Abigail Histed, Rachel Hsu, Natasha Jones and 5 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA; Population Studies Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA. Electronic address: ebakshis@umich.edu.
Joshua A GoodeSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Uma N HornishSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Devin P McNultySurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Thomas KaradimasSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Gillian AcedoDepartment of Psychology, University of Michigan, 1004 East Hall, Ann Arbor, MI 48109, USA.
Jaedyn BirchmierDepartment of Psychology, University of Michigan, 1004 East Hall, Ann Arbor, MI 48109, USA.
Abigail HistedDepartment of Psychology, University of Michigan, 1004 East Hall, Ann Arbor, MI 48109, USA.
Rachel HsuDepartment of Psychology, University of Michigan, 1004 East Hall, Ann Arbor, MI 48109, USA.
Natasha JonesDepartment of Psychology, University of Michigan, 1004 East Hall, Ann Arbor, MI 48109, USA.
Ryan TungDepartment of Psychology, University of Michigan, 1004 East Hall, Ann Arbor, MI 48109, USA.
Farah AmmousSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Edward D HuntleySurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Helen Cs MeierSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.
Colter M MitchellSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA; Population Studies Center, Institute for Social Research, University of Michigan, 426 Thompson St, Ann Arbor, MI 48104, USA.

Funding

DNA Methylation, Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort - Diversity SupplementR01AG067592 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2020 to 2025
$3.8M
Characterizing disparities in late-onset Alzheimer's disease risk through polygenic risk and epidemiologic factors in the Health and Retirement SurveyR01AG055406 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2017 to 2020
$1.7M
Genomics for Social Scientists: 2022-2027R25AG053227 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, COLTER M.S. MITCHELL · 2016 to 2026
$1.6M
NIA NIH HHS R01 AG055406NIA NIH HHS R01 AG067592NIA NIH HHS R25 AG053227NIMHD NIH HHS L60 MD012145
6 · The paper itself

Abstract

To better understand the relationship between DNA methylation summary measures and childhood behavioral and emotional problems, this scoping review synthesizes current research on the associations between DNA methylation and internalizing or externalizing traits or behaviors in children and adolescents. By identifying which psychological phenotypes are most consistently linked to DNA methylation summary measures and contextualizing research practices, this review highlights key methodological trends and gaps in the literature. Future research should include diverse and representative samples to enhance the generalizability and robustness of findings. Careful control for genetic ancestry, potential confounders, and adoption of standardized methodologies are important for improving the precision and interpretability of results. Additionally, a comprehensive examination of literature employing alternative DNA methylation methodologies, including epigenome-wide studies and pathway-based analytical approaches oriented toward mechanistic investigation, would afford greater insight into the interplay between DNAm and internalizing and externalizing symptomatology.

Indexed as

DNA MethylationEpigenesis, GeneticAdolescentChildHumansDNA methylationEpigenetic agingExternalizing behaviorInternalizing behaviorMethylation risk scoreScoping review

Identifiers

PMID41248785
PMCPMC12940123

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.