Evidence map›Paper›PMID 41249021›Full record

ArticleJournal of addiction medicine

Secondary Analysis to Advance Characterization of On-body Electrocardiographic Sensors in a Clinical Cocaine Self-administration Paradigm.

Gustavo A Angarita, Talia F Mayerson, Brian Pittman, Annamalai Natarajan, Abhinav Parate, Benjamin Marlin, Ralitza Gueorguieva, Marc N Potenza, Deepak Ganesan, Robert T Malison

Abstract read
In one paragraph

Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Gustavo A Angarita
Talia F Mayerson
Brian Pittman
Annamalai Natarajan
Abhinav Parate
Benjamin Marlin
Ralitza Gueorguieva
Marc N Potenza
Deepak Ganesan
Robert T Malison

Funding

Validation of a Remote Wireless Sensor Network (WSN) Approach to the IndividualizR01DA033733 · NIDA · YALE UNIVERSITY · PI GANESAN, DEEPAK, MALISON, ROBERT T · 2012 to 2013
$780k
NIDA NIH HHS R01 DA033733
6 · The paper itself

Abstract

objectivesOur group has previously established how remote on-body electrocardiogram (ECG) sensors may discriminate cocaine use from other sympathomimetic conditions. The current analyses assess whether discriminatory power is mainly driven by differences in heart rate between conditions.

methodsIndividuals who use cocaine (N = 11) wore ECG sensors during (1) cocaine self-administration, (2) methylphenidate administration, (3) aerobic exercise, and (4) tobacco use (N = 9). Primary outcomes included: (1) time elapsed between 2 successive R waves (ie, RR interval), (2) ECG interval proxies, and (3) waveforms. ECG traces were matched for heart rate between conditions for all discriminations.

resultsECG interval proxies and waveforms exhibited high discriminatory power in distinguishing cocaine use from methylphenidate, exercise, and tobacco use, with mean areas under the receiver operating characteristics ranging from 0.87 to 0.99, while RR-related measures ranged from 0.49 to 0.5, reflecting low discriminatory power.

conclusionOur results suggest that the ECG sensors' discriminatory power is based on nuances in ECG data beyond mere changes in heart rate.

Indexed as

Central Nervous System StimulantsCocaine-Related DisordersElectrocardiographyAdultCocaineExerciseFemaleHumansMaleMethylphenidateMiddle AgedSelf AdministrationCentral Nervous System StimulantsCocaineMethylphenidateaddictive behaviorscocaine detectioncocaine use disorderelectrocardiographyremote wireless sensors

Identifiers

PMID41249021
PMCPMC12624222

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.