ArticleRenal failure2025
Renal function and cognitive performance in older adults: a NHANES-based mediation analysis of methylmalonic acid as a marker of mitochondrial dysfunction.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Chronic kidney disease (CKD) is associated with cognitive impairment in older adults. Mitochondrial dysfunction (MD) is a key contributor to aging-related diseases, yet its potential role in mediating the relationship between renal function and cognitive function (CF) remains unclear. Therefore, we aimed to examine this association in older adults and to evaluate the mediating effect of MD. Our study analyzed data from the 2011-2014 National Health and Nutrition Examination Survey, including participants aged ≥60. CF was assessed using the Animal Fluency Test (AFT), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning Test, and the Digit Symbol Substitution Test (DSST). Multivariate linear regression models were used to explore the relationships between renal function and CF, CKD, and methylmalonic acid (MMA) levels, and CF. Mediation analysis was conducted to assess the role of MD, as reflected by serum MMA levels, in the link between renal function and cognitive impairment. A total of 2,437 participants aged ≥60 were included. Regression analysis showed a significant positive association between renal function and CF (β = 0.018, 95%CI: 0.013-0.024,
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