Evidence map›Paper›PMID 41249370›Full record

Trial reportScientific reports2025

Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design.

Stephen D Cousins, Samantha T C Kucewicz, Daniel W T Wundersitz, Blake E G Collins, Matthew B Cooke, Nicola McKeown, Hericka B Figueiredo Galvao, Stephanie M Resciniti, Phil M Lyristakis, Brett A Gordon and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephen D CousinsHolsworth Biomedical Research Centre, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Samantha T C KucewiczDepartment of Microbiology, Anatomy, Physiology, and Pharmacology, School of Life Sciences, La Trobe University, Bundoora, VIC, Australia.
Daniel W T WundersitzHolsworth Biomedical Research Centre, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Blake E G CollinsHolsworth Biomedical Research Centre, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Matthew B CookeSport, Performance, and Nutrition Research Group, School of Allied Health, Human Services, and Sport, La Trobe University, Melbourne, VIC, Australia.
Nicola McKeownHolsworth Biomedical Research Centre, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Hericka B Figueiredo GalvaoDepartment of Microbiology, Anatomy, Physiology, and Pharmacology, School of Life Sciences, La Trobe University, Bundoora, VIC, Australia.
Stephanie M RescinitiDepartment of Food, Nutrition and Dietetics, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, VIC, Australia.
Phil M LyristakisHolsworth Biomedical Research Centre, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Brett A GordonHolsworth Biomedical Research Centre, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Chris van der PoelDepartment of Microbiology, Anatomy, Physiology, and Pharmacology, School of Life Sciences, La Trobe University, Bundoora, VIC, Australia. c.vanderpoel@latrobe.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fucoidan extracted from brown algae has been shown to improve aerobic capacity and increase muscle size and strength in mice. Whether these beneficial effects translate to humans is unknown. This study investigated the effect of a resistance training program in combination with fucoidan supplementation on measures of strength and performance in apparently healthy adults. In a double-blind placebo control fashion, 20 participants (9 male and 11 female) were randomised to supplement with fucoidan (N = 10, 1 g/day) or placebo (N = 10, 1 g/day) during six weeks of resistance training. Body composition, muscle strength, anaerobic performance, and blood measurements were compared pre- and post-resistance training. Strength measured by 1 repetition max back squat was significantly increased in both placebo and fucoidan supplemented groups (p < 0.001), with no significant effect of treatment observed (p = 0.48). Peak power and relative peak power produced during a Wingate test were significantly increased in the fucoidan supplemented group only (p < 0.05). There was a significant treatment effect on body composition (p < 0.05), with the fucoidan supplemented group demonstrating a significant increase in lean body mass and a decrease in body fat % (p < 0.05). In conclusion, fucoidan supplementation during resistance training may provide a viable strategy for enhancing muscle anaerobic performance as well as improving metabolism and body composition.

Indexed as

Dietary SupplementsPolysaccharidesResistance TrainingAdultBody CompositionDouble-Blind MethodFemaleHumansMaleMuscle, SkeletalMuscle StrengthYoung AdultfucoidanPolysaccharidesAnaerobic metabolismBody compositionFucoidanResistance trainingSupplementation

Identifiers

PMID41249370
PMCPMC12624114

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.