SynthesisLasers in medical science2025
Effect of diode laser irradiation on stemness of dental Tissues - A systematic review.
Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of diode laser in pulpotomy: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental mesenchymal stem cells (DMSCs) are increasingly recognized for their regenerative properties, particularly in the context of pulp regeneration. Among the various treatment's diode laser irradiation, has gained more attention for its potential to promote stem cell differentiation, particularly osteogenic differentiation. To evaluate the effect of diode laser irradiation on the proliferation and osteogenic differentiation of dental tissue-derived mesenchymal stem cells. A comprehensive search was performed between January 2025 to June 2025 across five databases including PubMed, Cochrane Library, LILACA, Google scholar and ScienceDirect. Only in vitro studies that assessed cellular or osteogenic differentiation of DMSCS were included. The risk of bias for was assessed using the QUIN tool. A total of 21 studies were included in the review, encompassing various DMSC types, The studies explored a range of diode laser wavelengths (420-980 nm) and energy densities. Findings indicate that diode laser irradiation, particularly at wavelengths of 660 nm, 810 nm, and 980 nm, promotes osteogenic differentiation by enhancing the expression of osteogenic markers such as RUNX2, ALP, and OCN. The effect of diode laser irradiation on stem cell proliferation and osteogenic differentiation was found to be dose-dependent, with lower energy densities promoting proliferation and higher energy densities favoring differentiation. Diode laser irradiation at wavelengths of 660 nm, 810 nm, and 980 nm demonstrates potential for enhancing osteogenic differentiation of DMSCs. However, variability in laser parameters led to inconsistencies in the results, and no consensus could be reached regarding the optimal laser settings for maximum differentiation efficiency.
Indexed as
Identifiers
41249622What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.