Evidence map›Paper›PMID 41249665›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Improved outcomes of cyberknife stereotactic radiosurgery for spinal metastases: a retrospective study of sixty-one cases in one single center.

Paziliya Aikelamu, Zezhen Zhang, Wei Zou, Yun Guan, Rong Xie, Xin Wang

Abstract read
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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paziliya AikelamuDepartment of Neurosurgery Center, National Center for Neurological Disorders, Neurosurgical institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery Center, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China, Shanghai, China.
Zezhen ZhangDepartment of Neurosurgery Center, National Center for Neurological Disorders, Neurosurgical institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery Center, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China, Shanghai, China.
Wei ZouDepartment of Neurosurgery Center, National Center for Neurological Disorders, Neurosurgical institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery Center, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China, Shanghai, China.
Yun GuanDepartment of Neurosurgery Center, National Center for Neurological Disorders, Neurosurgical institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery Center, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China, Shanghai, China.
Rong XieDepartment of Neurosurgery Center, National Center for Neurological Disorders, Neurosurgical institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery Center, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China, Shanghai, China. rongxie@fudan.edu.cn.
Xin WangDepartment of Neurosurgery Center, National Center for Neurological Disorders, Neurosurgical institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery Center, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China, Shanghai, China. wangxinck@fudan.edu.cn.

Funding

Joint Funds for the Innovation of Science and Technology, Fujian Province No.2021Y9307 and 2023Y9114National Natural Science Foundation of China(NSFC) (82071315, and 82271342)Natural Science Foundation of Fujian Province 2023J01314
6 · The paper itself

Abstract

purposeStereotactic radiosurgery (SRS) is a commonly employed treatment for spinal metastases (SMs). Although the outcomes of hybrid therapy have been extensively documented, there is limited research on the definitive effectiveness of SRS, particularly CyberKnife (CK), which remains inadequately defined. This study seeks to assess the effectiveness of CK SRS for patients with SMs.

methodsA retrospective, single-institution, study was conducted on patients with SMs who exclusively underwent CK treatment at a major university hospital between January 2021 and June 2024. Primary outcomes were local control (LC). Secondary outcomes included overall survival (OS), pain assessment (Numeric Rating Scale, NRS), functional status (Karnofsky Performance Status, KPS), and treatment-related toxicity.

resultsSixty-one patients underwent CK treatment with a median follow-up of 10 months, without surgical intervention at the treated site. The 6-month and 12-month survival rates were 96. 4% and 94. 2%, respectively, while LC rates were 94. 6% and 92. 5%. Patient-reported outcomes demonstrated a significant improvement in pain relief, with a decrease in the NRS score from a pre-CK median of 3. 0 to a post-CK median of 2. 0 (P < 0. 001). Additionally, there was no significant difference in KPS scores before and after treatment.

conclusionCK SRS provides effective local control, pain relief, and minimal toxicity in selected patients with spinal metastases without prior surgery and low-to-intermediate grade compression. Results are consistent with established SBRT literature. Multi-institutional validation studies are warranted.

Indexed as

RadiosurgerySpinal NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeCyberKnifeSpine metastasesStereotactic radiosurgery

Identifiers

PMID41249665

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.