ArticleDiscover mental health2025
Associations of uric acid and lipids with depression, dimensions of depression and anxiety symptoms.
Article in Discover mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Age-dependent association of uric acid levels with depressive symptoms in adults: NHANES 2007-2018.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiscovering biological correlates of depression (and symptom dimensions) and anxiety is a topic of ongoing research. We aimed to examine the associations of uric acid (UA) and lipids with depression (sum and emotional, neurovegetative, cognitive dimension) and anxiety symptoms.
methodsParticipants were screened for depression and anxiety symptoms using the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7) questionnaires, respectively, in primary care in Greece during January-June 2022. Serum UA and lipids were recorded and socio-demographic, behavioral, and personal history covariates were also collected. Poisson regression analyses were performed to determine associations between recorded parameters and the PHQ-9 (sum-score and emotional, neurovegetative, cognitive dimension) and GAD-7 scores.
resultsA total of 181 individuals answered the questionnaires. The mean age was 61.8 ± 10.8 years, and 68% were female. The prevalence of clinically significant depression (PHQ-9 ≥ 10) and anxiety (GAD-7 ≥ 10) symptoms was 20.4%, respectively. PHQ-9 score was negatively associated with UA, high-density lipoprotein cholesterol (HDL-C) and income, and positively with low-density lipoprotein cholesterol (LDL-C) and physical activity. The neurovegetative dimension of the PHQ-9 score was negatively associated with UA and HDL-C, while the cognitive was positively associated with LDL-C. GAD-7 score was negatively associated with HDL-C and income, and positively with LDL-C and physical activity, while it was higher in females and smokers.
conclusionsBoth UA and lipids were associated with depression and anxiety symptoms. The neurovegetative and cognitive symptoms of depression exhibited different biological correlates with low UA and HDL-C, and high LDL-C, respectively.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.