ArticleHypertension research : official journal of the Japanese Society of Hypertension2026
Regional disparities in blood pressure control after hypertension treatment initiation in Japan: a real-world data analysis.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Oral Health and Cardiovascular Disease Among Hypertensive Medicated Adults With Uncontrolled Blood Pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- It is indeed necessary to go back to basics.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Current hypertension epidemiology and contemporary approaches using the "Real-World Evidence Cycle" framework.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study assessed regional variations in blood pressure (BP) control after antihypertensive treatment and explored the associations with healthcare resource indicators across Japan. Using nationwide health check-up data from the Japan Health Insurance Association between 2015 and 2022, we analyzed 1,318,437 individuals aged 40-74 who initiated antihypertensive treatment based on consecutive health check-ups. We evaluated prefecture-level differences in post-treatment BP control rates (systolic BP [SBP]/diastolic BP [DBP] <130/<80 mmHg). Prefecture-level ecological analyses examined the associations between adjusted BP control rates and cerebrovascular disease mortality rates and six healthcare resource indicators, including the Physician Uneven Distribution Index (PUDI). Mean SBP/DBP decreased from 148.3/92.4 mmHg to 134.1/83.1 mmHg following treatment initiation. Only 26.7% of patients achieved the target BP (<130/<80 mmHg). This level is the universal target in the Japanese Society of Hypertension Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025, highlighting a significant public health challenge. Unadjusted BP control rates varied by 10.2% across prefectures, narrowing to 7.4% after adjusting for individual-level patient characteristics. Pre-treatment SBP was the strongest predictor of post-treatment BP control. Ecological analysis revealed that each 1% increase in patients achieving the target BP of <130/<80 mmHg was associated with 3.5 fewer cerebrovascular disease deaths per 100,000 population in both sexes. PUDI showed a significant positive association with BP control rate (weighted Pearson's r = 0.47; p < 0.001). In conclusion, substantial regional disparities in BP control persist across Japan, which are significantly influenced by physician availability and associated with differences in stroke mortality. Using Japanese nationwide health check-up data from 1.3 million individuals initiating antihypertensive treatment, only 26.7% achieved the target BP (<130/<80 mmHg). Adjusted BP control rates varied by 7.4% across prefectures and were positively associated with physician availability and inversely with stroke mortality, indicating the impact of regional healthcare resource disparities.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.