Evidence map›Paper›PMID 41249950›Full record

Observational studyBMC nephrology2025

Prevalence, severity, and determinants of CKD-associated pruritus in a Swiss hemodialysis population with widespread use of hemodiafiltration: a cross-sectional study.

Nancy Helou, Dina Nobre, Tanguy Corre, Olivier Bonny, Robin Chazot, Anne Cherpillod, Sophie De Seigneux, David Fumeaux, Zina Fumeaux, Antoine Humbert and 11 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05524467 (RELIEF CENSUS-EU), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05524467 completednot on this map

RELIEF CENSUS-EU: Cross-sectional Study to Assess Prevalence and Burden of CKD-associated Pruritus in Haemodialysis Patients

TypeobservationalSponsorVifor (International) Inc.Ran2023 to 2024Enrolled3,100ConditionsChronic Kidney Disease-associated Pruritus
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nancy HelouSchool of Health Sciences (HESAV), HES-SO University of Applied Sciences and Arts Western Switzerland, Avenue de Beaumont 21, Lausanne, 1011, Switzerland. nancy.helou@hesav.ch.ORCID 0000-0001-6443-8122
Dina NobreService of Nephrology and Hypertension, University Hospital of Lausanne and University of Lausanne (CHUV), Lausanne, Switzerland.
Tanguy CorreService of Nephrology and Hypertension, University Hospital of Lausanne and University of Lausanne (CHUV), Lausanne, Switzerland.
Olivier BonnyService of Nephrology, Hôpital de Fribourg (HFR) and University of Fribourg, Fribourg, Switzerland.
Robin ChazotDialyse Riviera, Vevey, Switzerland.
Anne CherpillodDialysis Center, Clinique Cecil, Lausanne, Switzerland.
Sophie De SeigneuxService of Nephrology, Geneva University Hospitals (HUG), Geneva, Switzerland.
David FumeauxDialysis Center, Clinique Cecil, Lausanne, Switzerland.
Zina FumeauxDialysis Center, Nyon Hospital, Nyon, Switzerland.
Antoine HumbertService of Nephrology, Réseau Hospitalier Neuchâtelois, Neuchâtel, Switzerland.
David JaquesService of Nephrology, Geneva University Hospitals (HUG), Geneva, Switzerland.
Ould Maouloud HemettService of Nephrology, Hôpital de Fribourg (HFR) and University of Fribourg, Fribourg, Switzerland.
Patricia MehierDialysis Center, Hôpital Riviera-Chablais, Rennaz, Switzerland.
Grzegorz NowakDialysis Center, Hôpital du Valais - Centre Hospitalier du Valais Romand (CHVR), Hôpital de Sierre, Sierre, Switzerland.
Olivier PhanHemodialysis Center, Broye Intercantonal Hospital, Payerne, Switzerland.
Anne-Hélène RebouxDialysis Center, Hôpital du Valais - Centre Hospitalier du Valais Romand (CHVR), Hôpital de Martigny, Martigny, Switzerland.
Alain RossierDialysis Center, Hôpital Riviera-Chablais, Rennaz, Switzerland.
Floriane SeydtaghiaDialysis Center, Etablissements Hospitaliers du Nord Vaudois (eHnv), Yverdon-les-Bains, Switzerland.
Daniel TetaDialysis Center, Hôpital du Valais - Centre Hospitalier du Valais Romand (CHVR), Hôpital de Sierre, Sierre, Switzerland.
Gérard VogelDialysis Center, Hôpital Riviera-Chablais, Rennaz, Switzerland.
Menno PruijmService of Nephrology and Hypertension, University Hospital of Lausanne and University of Lausanne (CHUV), Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic Kidney Disease Associated-Pruritus (CKD-aP) is frequent among hemodialysis patients. Its associations with hemodiafiltration or conventional hemodialysis and clinical characteristics are inconsistent in observational studies. This study aimed to assess the prevalence, severity and factors associated with CKD-aP among patients on hemodialysis in the French-speaking part of Switzerland, where hemodiafiltration is widely used.

methodsA cross-sectional design was used. Adults on hemodialysis for ≥ 6 months and free of cognitive impairment were recruited from 15 dialysis centers. A research nurse collected sociodemographic, clinical, laboratory data and assessed CKD-aP using the Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS). A multilevel mixed-effects model with maximum likelihood estimation was performed to investigate associations.

resultsA total of 413 participants, mean age was 69.68 years (SD 13.52), were included; 66% were men, 73% on hemodiafiltration. CKD-aP prevalence was 25%. VAS average itch score of participants with CKD-aP was 4.74 ± 1.99, versus 6.62 ± 2.18 for the worst intensity itch. According to VRS, most participants with CKD-aP suffered moderate (61.4%) to severe (22%) itch within the past 24 h. Higher phosphorus levels were significantly associated with increased CKD-aP severity, but not prevalence. Depression, smoking, and polypharmacy were associated with increased CKD-aP severity, whereas hemodialysis modality, volume substitution, filter or access type were not.

conclusionsDespite high dialysis standards, CKD-aP remains a frequent symptom in Switzerland. Depression is associated with CKD-aP and its severity while hemodialysis modality is not. These results suggest that effective management of CKD-aP requires not only optimal dialysis prescription but also a holistic approach.

trial registrationRegistered at ClinicalTrials.gov (NCT05524467) on 10.06.2022.

Indexed as

HemodiafiltrationPruritusRenal DialysisRenal Insufficiency, ChronicAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceSeverity of Illness IndexSwitzerlandChronic hemodialysisChronic kidney disease-associated pruritusItchItch severityPatient-reported outcomes

Identifiers

PMID41249950
PMCPMC12625539

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.