Evidence map›Paper›PMID 41250117›Full record

ReviewNeurological research and practice2025

Environmental toxins in neurodegeneration - a narrative review.

Kristína Kulcsárová, Johannes Heinrich Alexander Piel, Eva Schaeffer

Abstract readReview
In one paragraph

Review in Neurological research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Preventive strategies in neuroimmunology.Neurological research and practice · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristína Kulcsárová *Department of Neurology, P. J. Safarik University, Kosice, Slovak Republic.
Johannes Heinrich Alexander Piel *Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, 24105, Kiel, Germany.
Eva SchaefferDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, 24105, Kiel, Germany. eva.schaeffer@uksh.de.ORCID http://orcid.org/0000-0002-0792-4383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the global incidence of neurodegenerative disorders rises at a rate beyond what can be attributed solely to population aging, the role of modifiable risk factors has come into research spotlight to inform preventive strategies. While many lifestyle interventions can be implemented at an individual level, addressing environmental pollutants that drive neurodegeneration requires a collective effort involving both public and political engagement. This narrative review summarizes current evidence on the role of selected environmental toxins-pesticides, solvents, air pollution, and heavy metals-in the development of Parkinson's Disease, Alzheimer's Disease, and Amyotrophic Lateral Sclerosis. Drawing from epidemiological and experimental studies, we highlight associations between these exposures and neurodegeneration, as well as potential converging pathophysiological mechanisms such as neuroinflammation and proteinopathy. Understanding these links may help inform public health measures aimed at reducing the burden of these diseases.

Indexed as

Air pollutionAlzheimer’s diseaseAmyotrophic lateral sclerosisEnvironmental toxinsHeavy metalsNeurodegenerationParkinson’s diseasePesticidesSolvents

Identifiers

PMID41250117
PMCPMC12625418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.