ReviewJournal of anesthesia, analgesia and critical care2025
Analgesic and sedative drug dosing in critically ill patients with Acute Kidney Injury undergoing different modalities of Kidney Replacement Therapy.
Review in Journal of anesthesia, analgesia and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of midazolam versus dexmedetomidine in mechanically ventilated intensive care unit patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- From Intelligent Operating Room to Smart ICU: Digital Continuity, AI-Supported Decision-Making and CRRT as a Model of Pharmacokinetic Personalization in Critical Care.Healthcare (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critically ill patients frequently require analgesic and sedative medications to manage pain, agitation, and the stress associated with their condition. The onset of Acute Kidney Injury (AKI) can complicate the pharmacokinetics of these drugs, requiring careful dose adjustments to prevent adverse effects. Additionally, Kidney Replacement Therapy (KRT) may further influence drug metabolism and clearance. As renal dysfunction may alter the elimination of these medications, a comprehensive understanding of their pharmacologic profiles and the impact of KRT is essential for optimizing pain and sedation management in critically ill patients. In particular, this review explores the challenges and strategies involved in dosing analgesic and sedative drugs in critically ill patients with AKI undergoing various KRT modalities, including intermittent hemodialysis (IHD), continuous kidney replacement therapy (CKRT), and prolonged intermittent kidney replacement therapy (PIKRT). Moreover, this narrative review is aimed at summarizing existing evidence on pharmacokinetic alterations, clearance rates and eventual dose adjustments in critically ill patients with AKI undergoing various KRT modalities. Special emphasis is placed on the effects of different KRT modalities on drug elimination and associated therapeutic implications, seeking to provide healthcare professionals with evidence-based guidelines for the safe and effective administration of analgesics and sedatives in this complex, high-risk patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.