Evidence map›Paper›PMID 41250558›Full record

Observational studyActa obstetricia et gynecologica Scandinavica2026

Cardiac dysfunction during adverse maternal outcomes in hypertensive disorders of pregnancy.

Veronica Giorgione, Jamie Kitt, Paul Leeson, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan

Abstract readObservational Study
In one paragraph

Observational study in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Veronica GiorgioneFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0003-3991-9308
Jamie KittOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Paul LeesonOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Asma KhalilFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0003-2802-7670
Jamie O'DriscollDepartment of Cardiology, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-5923-4798
Basky ThilaganathanFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-5531-4301

Funding

iPLACENTA project 765274
6 · The paper itself

Abstract

introductionHypertensive disorders of pregnancy are associated with significant cardiac remodeling and diastolic dysfunction during pregnancy and are important contributors to maternal morbidity and mortality. Whether acute adverse maternal outcomes during hypertensive disorders of pregnancy are associated with abnormal left ventricular geometry and function has not been widely studied. MATERIAL AND

methodsA prospective observational study was conducted on 255 women with hypertensive disorders of pregnancy who underwent transthoracic echocardiography during the peripartum period. Maternal echocardiographic parameters, including left ventricular morphology and function, were analyzed to determine their association with composite adverse maternal outcomes by univariate and multivariate analyses. The composite adverse maternal outcome was defined as at least one of the following: admission to a high dependency unit (an intermediate-care ward, providing enhanced cardiac monitoring), acute renal injury, adverse cardiopulmonary events, stroke, and disseminated intravascular coagulation.

resultsAdverse maternal outcomes occurred in 68 (26.7%) participants. Women with adverse outcomes had significantly higher left atrial volume index (28.8 [23.4-32.3] mL/m

conclusionsCardiac abnormalities, particularly in left ventricular diastolic function and in right ventricular function, are more common in women with adverse maternal outcomes in hypertensive disorders of pregnancy than in hypertensive women without adverse maternal outcomes. Further studies are needed to determine whether these echocardiographic abnormalities could help identify women at increased risk of complications.

Indexed as

Hypertension, Pregnancy-InducedVentricular Dysfunction, LeftAdultEchocardiographyFemaleHumansPregnancyPregnancy OutcomeProspective Studiesadverse maternal outcomeshypertensionpre‐eclampsiapregnancytransthoracic echocardiography

Identifiers

PMID41250558
PMCPMC12856716

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.