SynthesisAnnals of medicine2025
Exercise-induced modulation of IGF-1 in healthy, obese, and cancer populations: a systematic review and meta-analysis.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Association Between Physical Activity and Mortality in Men with or at Risk of Prostate Cancer: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- The regulatory effects of growth hormone on adipose tissue at physiological and pathological levels and its relationship with obesity.International journal of obesity (2005) · 2026Review
- Exercise mimetics: molecular mechanisms, biological and therapeutic effects.Molecular biomedicine · 2026Review
- The Myokinib monograph: operationalizing oncology's highest-value systemic therapeutic.The oncologist · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review and meta-analysis evaluated the effects of chronic exercise on circulating insulin-like growth factor 1 (IGF-1) across different populations, including, healthy adults, individuals with obesity, and cancer patients or survivors. To minimize confounding, we excluded trials combining exercise with medications, hormone therapy, or structured dietary interventions. MATERIALS AND
methodsPubMed and Embase were searched through July 2024 for randomized controlled trials (RCTs) in adults (≥18 years) with exercise interventions lasting ≥8 weeks, a non-exercise control group, and reported changes in serum IGF-1. Twenty-one RCTs with 1376 participants met the inclusion criteria. Pooled weighted mean differences (WMD) with 95% confidence intervals (CI) were calculated, and trial sequential analysis was used to assess robustness.
resultsExercise significantly increased IGF-1 in healthy individuals (WMD=21.41, 95% CI 8.01-34.81) and in those with obesity (WMD=15.46, 95% CI -1.07-31.99), consistent with metabolic and anabolic benefits via the GH-IGF-1 axis. In contrast, exercise significantly reduced IGF-1 in cancer patients or survivors (WMD=-14.71, 95% CI -19.77 to -9.65). In studies reporting both IGF-1 and IGF-binding protein 3 (IGFBP-3), exercise increased IGFBP-3 in healthy and cancer populations, suggesting a modulatory role of IGFBP-3 in IGF-1 regulation, particularly in cancer.
conclusionChronic exercise exerts health status-dependent effects on circulating IGF-1, supporting metabolic benefits in healthy and obese individuals and potentially contributing to cancer care by reducing IGF-1 in cancer patients or survivors. These findings demonstrate the complex endocrine response to exercise and support the therapeutic potential of tailored exercise prescriptions. .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.