Evidence map›Paper›PMID 41250892›Full record

ArticleThe FEBS journal2026

Co-localization of tau and TDP-43 after extracellular vesicle delivery to cells.

Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J Strong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farhang AliakbariMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Kathryn VolkeningMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Zahra NayeriDepartment of Bioprocess Engineering, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Aysegul Yucel PolatMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Neil DonisonMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Jacqueline PalikMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Michael J StrongMolecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.ORCID 0000-0003-1988-6262

Funding

CIHR 201806SOP-411481
6 · The paper itself

Abstract

Perturbations in the metabolism of microtubule-associated protein tau (tau) underlie the pathology of a broad array of dementias, including chronic traumatic encephalopathy, amyotrophic lateral sclerosis (ALS) with cognitive impairment (ALSci) and approximately half of the dementias associated with frontotemporal lobar degeneration. We recently observed significantly increased hippocampal tau pathology in rats injected with pseudophosphorylated human tau (2N4R tau

Indexed as

DNA-Binding ProteinsExtracellular Vesiclestau ProteinsAmyotrophic Lateral SclerosisAnimalsHEK293 CellsHumansRatsDNA-Binding ProteinsMAPT protein, humanTARDBP protein, humantau Proteinsamyotrophic lateral sclerosisextracellular vesiclesfrontotemporal lobar degenerationneurodegenerationtauopathy

Identifiers

PMID41250892
PMCPMC12958098

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.