ArticleHistology and histopathology2026
WuFu decoction alleviates osteoarthritis by regulating TGF-β1/Smad and ERK1/2 pathways.
Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The age-standardized point prevalence of global osteoarthritis (OA) has increased, and OA will not only lead to disability in patients but also to a greater psychological burden. In recent years, the focus of scientists on treating OA has turned to disease prevention and treatment of early OA. Previous studies have proved that WuFu Decoction (WFD) could protect chondrocytes, and the Chinese herbs in this prescription have shown anti-inflammatory effects. In this study, we built the OA rat model by the modified Hulth method, conducted research with WFD, and set D-Glucosamine sulfate as the positive control. It is proven that WFD improved the micromorphology and tissue damage of the knee joint, decreased the score of the Mankin and OARSI system, and inhibited the IL-1β, TNF-α, MMP-13, and CTX-1 levels in serum. Additionally, WFD treatment inhibited p-ERK1/2 levels and raised the mRNA and protein levels of TGF-β1, p-Smad2, p-Smad3, type II collagen (the gene is
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