Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design.

Kane A C Bastick, Caleb E Griesbach, Ben Zhen Huang, Morgan J Cordell, Yang Daniel Ou, Alán Aspuru-Guzik, Andrei K Yudin

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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design.Angewandte Chemie (International ed. in English) · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kane A C Bastick *Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

Caleb E Griesbach *Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

Ben Zhen HuangDepartment of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

Morgan J CordellDepartment of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

Yang Daniel OuDepartment of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

Alán Aspuru-GuzikDepartment of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

Andrei K YudinDepartment of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.ORCID https://orcid.org/0000-0003-3170-9103

Funding

Merck Research LaboratoriesNatural Sciences and Engineering Research Council of Canada RGPIN-2024-04343The Acceleration Consortium, University of Toronto

6 · The paper itself

Abstract

Chemists continue to develop strategies that leverage abundant feedstocks to accelerate the production of medicines, agrochemicals, and materials. Oligoheterocycles are a broad class of molecules that span these disciplines. Cross-coupling strategies are commonly used to assemble oligoheterocycles; however, these methods can be challenging and often rely on precious metal catalysts and building blocks whose production entails significant environmental and economic costs. We present a strategy for the iterative construction of oligoheterocycles that leverages sustainable building blocks designed around high-oxidation-state carbon. By utilizing feedstocks from the base of the chemical supply chain, we generate bifunctional building blocks that chemoselectively engage with a variety of partners through simple condensation manifolds. This approach has enabled the creation of novel scaffolds previously inaccessible by conventional means, exemplifying sustainable design strategies.

Indexed as

Cross‐condensationFrame‐shifted synthesisHeterocyclesSynthesis designSynthetic methods

Identifiers

PMID41251141

DOI10.1002/anie.202520677

PMCPMC12790365

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.