ReviewClinical science (London, England : 1979)2025
Central leptin pathways in metabolic homeostasis.
Review in Clinical science (London, England : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Leptin, adiponectin levels and their ratios in women with polyendocrine metabolic ovarian syndrome: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Adipokines as Regulators of Nitric Oxide Synthase Isoforms Across Organs: Emerging Implications for Gastrointestinal Motility.International journal of molecular sciences · 2026Review
- Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.Clinical science (London, England : 1979) · 2026Review
- Secretion Patterns of Leptin: A Key Component in the Regulation of Energy Homeostasis and Its Therapeutic Applications.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity continues to be a major global health crisis, contributing to the rising prevalence of metabolic disorders such as type 2 diabetes, cardiovascular disease, and certain cancers. Central to the regulation of energy homeostasis is the adipocyte-derived hormone leptin, which serves as a key afferent signal to the central nervous system to suppress food intake, enhance energy expenditure, and maintain glucose balance. Since its discovery over three decades ago, a wealth of research has illuminated the molecular, cellular, and physiological mechanisms through which leptin exerts its metabolic effects. These foundational studies have delineated the neural circuits, particularly within the hypothalamus and brainstem, that integrate leptin signaling to co-ordinate complex metabolic responses. This review provides a comprehensive synthesis of the current understanding of leptin's metabolic actions, with an emphasis on the intracellular signaling cascades that mediate leptin receptor activation. We also highlight the diverse neuronal populations and brain regions that contribute to leptin's regulatory roles.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.