ArticleAAPS PharmSciTech2025
HSPiP and Neuro-Fuzzy Model-Enabled Optimized Nanoemulsions for Nose-to-Brain Delivery of Valproic Acid.
Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The present work is the extended findings of our previous study on valproic acid (VA)-loaded cationic nanoemulsions for HSPiP and Neuro-fuzzy model (ANFIS)-enabled optimized composition to attain targeted permeation flux, the influence of permeation enhancers, and characterizations of the optimized product. The binding efficiency of the formulations with nasal mucus was assessed. The pH dependent in-vitro drug release (dialysis membrane) study, ex-vivo permeation assessment using a goat nasal mucosa, and benchtop physically stable at room temperature, were investigated. The fluorescence microscopy (FM) study compared the penetration potential across the nasal mucosa. The cationic nanoemulsions exhibited low particle size range (29-373 nm), narrow distribution (0.12-0.37), and high zeta potential (22-35.7 mV). HSPiP-generated permeation flux (Y
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