Evidence map›Paper›PMID 41251983›Full record

ArticleEJNMMI research2025

First-in-human intranasal [

Michael Winterdahl, Erik Nguyen Nielsen, Søren B Hansen, André Henrique Dias, Mikkel Holm Vendelbo, Steen Jakobsen, David Yeomans

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06955650 (First-in-man Imaging of a New PET Radiotracer for Oxytocin Receptors - Biodistribution and Radiation Dosimetry), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06955650 early_phase1completednot on this map

First-in-man Imaging of a New PET Radiotracer for Oxytocin Receptors - Biodistribution and Radiation Dosimetry

TypeinterventionalSponsorAarhus University HospitalRan2021 to 2022Enrolled6ConditionsPain, FaceArmsImaging procedure to measure the distribution of a newly developed radiolabeled ligand for the oxytocin receptor
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael WinterdahlSexological Centre, Aalborg University Hospital, Aalborg, Denmark. m.winterdahl@rn.dk.ORCID http://orcid.org/0000-0002-8790-7574
Erik Nguyen NielsenDepartment of Nuclear Medicine PET-Centre, Aarhus University Hospital, Aarhus, Denmark.
Søren B HansenDepartment of Nuclear Medicine PET-Centre, Aarhus University Hospital, Aarhus, Denmark.
André Henrique DiasDepartment of Nuclear Medicine PET-Centre, Aarhus University Hospital, Aarhus, Denmark.
Mikkel Holm VendelboDepartment of Nuclear Medicine PET-Centre, Aarhus University Hospital, Aarhus, Denmark.
Steen JakobsenDepartment of Nuclear Medicine PET-Centre, Aarhus University Hospital, Aarhus, Denmark.
David YeomansDepartment of Anaesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxytocin is a neuropeptide with therapeutic potential for several neuropsychiatric and pain-related disorders. Intranasal delivery is proposed to enable access to the central nervous system via the trigeminal nerve and olfactory nerves, thereby bypassing the blood-brain barrier. However, direct evidence of biodistribution following intranasal administration in humans is limited. This study evaluated the feasibility of imaging oxytocin uptake using a novel PET tracer, [

resultsSix participants received intranasal [

conclusionsIntranasal [

trial registrationClinicalTrials.gov identifier: NCT06955650 (registered May 5, 2025).

Indexed as

Brain imagingIntranasal administrationOxytocinPharmacokineticsPositron emission tomographyTrigeminal nerve

Identifiers

PMID41251983
PMCPMC12627303

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.