In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Momono YamauchiDepartment of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.ORCID 0009-0009-1660-6561 Dohyun ImDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.ORCID 0000-0002-6939-7718 Shintaro MaedaDepartment of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.ORCID 0000-0002-8932-2051 Tatsuya IkutaLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.ORCID 0000-0002-8597-0609 Masayasu ToyomotoDepartment of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.ORCID 0000-0002-3110-1387 Hidetsugu AsadaDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Yukihiko SugitaLaboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.ORCID 0000-0001-6861-4840 Jun-Ichi KishikawaFaculty of Applied Biology, Kyoto Institute of Technology, Matsugasaki Hashikami-cho, Sakyo-ku, Kyoto 606-8585, Japan.
Takeshi NodaLaboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.ORCID 0000-0002-0658-4663 Asuka InoueLaboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.ORCID 0000-0003-0805-4049 So IwataDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Masatoshi HagiwaraDepartment of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.ORCID 0000-0003-1193-7571 Funding
Japan Agency for Medical Research and Development (AMED) JP22ama121038Japan Agency for Medical Research and Development (AMED) JP22zf0127007Japan Agency for Medical Research and Development (AMED) JP23ama121001Japan Agency for Medical Research and Development (AMED) JP23ama121007Japan Agency for Medical Research and Development (AMED) JP23ck0106813MEXT | Japan Science and Technology Agency (JST) JPMJFR215TMEXT | Japan Science and Technology Agency (JST) JPMJMS2023MEXT | Japan Society for the Promotion of Science (JSPS) 22KK0099MEXT | Japan Society for the Promotion of Science (JSPS) 23K06357MEXT | Japan Society for the Promotion of Science (JSPS) 24K21945MEXT | Japan Society for the Promotion of Science (JSPS) JP21H04791MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05042MEXT | Japan Society for the Promotion of Science (JSPS) JP22K08282MEXT | Japan Society for the Promotion of Science (JSPS) JP24K21281MEXT | JST | Program for Creating STart-ups from Advanced Research and Technology (START) JPMJST2181
6 · The paper itselfAbstract
Sphingosine-1-phosphate (S1P) is one of the most extensively studied bioactive lipids that transduces signals via the S1P receptor (S1PR) family (S1PR1-5), a class of G-protein-coupled receptors (GPCRs), to regulate immune cell migration, vascular permeability, and pain modulation. However, the mechanism for achieving specificity in downstream signaling remains poorly understood. Here, we present cryogenic electron microscopic structures of the S1PR3-G
Indexed as
GTP-Binding Protein alpha Subunits, Gq-G11Receptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsBinding SitesCryoelectron MicroscopyHumansLysophospholipidsModels, MolecularProtein BindingSignal TransductionSphingosineGTP-Binding Protein alpha Subunits, Gq-G11LysophospholipidsReceptors, LysosphingolipidSphingosinesphingosine 1-phosphatesphingosine-1-phosphate receptor-3, humanSphingosine-1-Phosphate Receptorsbiased agonismcryo-electron microscopyG protein-coupled receptorG protein selectivitystructure
Identifiers
PMID41252158
PMCPMC12663997
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390