ArticleJournal of medicinal chemistry2025
Optimization of Prodiginines as Single-Dose Curative Antimalarials.
Abstract read
In one paragraph
Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Revisiting 2-Substituted-4(1Journal of medicinal chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors.
Amrendra KumarDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.
Yuexin LiDepartment of Veterans Affairs Medical Center, Portland VA Medical Center as the Institution, Portland, Oregon 97239, United States.
Xiaowei ZhangDepartment of Veterans Affairs Medical Center, Portland VA Medical Center as the Institution, Portland, Oregon 97239, United States.
Mahesh GaddamDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0009-0000-8182-659X
Diana CaridhaExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Michael S MadejczykExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Xiannu JinExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
William E DennisExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Ravi ChetreeExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Cameron BlountExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Jesse DeLucaExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Chau VuongExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Karl KudybaExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Norma RoncalExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Kutub AshrafExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Patricia J LeeExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Kristina PannoneExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Susan LeedExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Hieu T DinhExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Kennedy MdakiExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Kimberly NavarreteDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Jordan CharltonDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Angely J BinauhanDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Tarrick QahashDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Kevin Mugambi KibeDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Douglas A ShoueDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Lisa CheckleyDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Michael T FerdigDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Anongruk Chim-OngDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
Liwang CuiDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.
Stephen OrenaInfectious Diseases Research Collaboration, Kampala, Uganda.
Oswald ByaruhangaInfectious Diseases Research Collaboration, Kampala, Uganda.
Jackson AssimweInfectious Diseases Research Collaboration, Kampala, Uganda.
Innocent TibagambirwaInfectious Diseases Research Collaboration, Kampala, Uganda.
Sivanna ChithannaDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.
Rozalia A DodeanDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0001-5002-4607
Jennifer LegacDepartment of Medicine, University of California San Francisco, San Francisco, California 94143, United States.
Oriana KreutzfeldDepartment of Medicine, University of California San Francisco, San Francisco, California 94143, United States.
Philip J RosenthalDepartment of Medicine, University of California San Francisco, San Francisco, California 94143, United States.
Roland A CooperDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Kevin A ReynoldsDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0003-0270-9809
Alison RothExperimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.
Jane X KellyDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0001-8871-0207
Papireddy KancharlaDepartment of Chemistry, Portland State University, Portland, Oregon 97201, United States.ORCID 0000-0002-6381-1236
Funding
Systems genetics of artemisinin resistanceP01AI127338 · NIAID · UNIVERSITY OF NOTRE DAME · PI Michael T Ferdig · 2017 to 2026
$21.3MResistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4MMechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3MNovel Multiple-Stage Active AntimalarialsR01AI141972 · NIAID · PORTLAND STATE UNIVERSITY · PI JANE X KELLY, Papireddy Kancharla · 2019 to 2026
$4.5MUnraveling the Drivers of Persistent Malaria Transmission in Cameroon: A Systems Approach (REDIAL)U19AI181593 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI LIWANG CUI · 2024 to 2026
$3.0MNatural Product Inspired Novel Antimalarials with Radical Cure PotentialR01AI175444 · NIAID · PORTLAND STATE UNIVERSITY · PI JANE X KELLY, Papireddy Kancharla · 2023 to 2026
$2.5MNIAID NIH HHS P01 AI127338NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI139179NIAID NIH HHS R01 AI141972NIAID NIH HHS R01 AI175444NIAID NIH HHS U19 AI181593
Abstract
The emergence of drug-resistant malaria underscores the urgent need for novel, well-tolerated antimalarials with multistage activity and distinct mechanisms of action. Here, we report the design and synthesis of 54 new prodiginine (PG) analogs through systematic modification of the B and C rings of the core scaffold. This effort led to the identification of lead compound PG102 (
Indexed as
AntimalarialsMalariaProdigiosinAnimalsDrug ResistanceFemaleHumansMicePlasmodium bergheiPlasmodium falciparumPlasmodium yoeliiStructure-Activity RelationshipAntimalarialsprodiginineProdigiosin
Identifiers
What Socratic holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.