Evidence map›Paper›PMID 41253491›Full record

ArticleJournal for immunotherapy of cancer2025

Prognosis and treatment response stratification according to loss of proofreading (LOP)

Giulia Maddalena, Fadl A Zeineddine, Saikat Chowdhury, Mohammad A Zeineddine, Abdelrahman M Yousef, Francesca Bergamo, Sara Lonardi, Timothy A Yap, Michael Geoffrey White, Michael J Overman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giulia Maddalena *Gastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-1714-1171
Fadl A Zeineddine *Gastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA.
Saikat ChowdhuryGastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA.
Mohammad A ZeineddineGastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA.
Abdelrahman M YousefUniversity of New Mexico Hospital, Albuquerque, New Mexico, USA.
Francesca BergamoOncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.
Sara LonardiOncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.ORCID http://orcid.org/0000-0002-7593-8138
Timothy A YapDepartment of Investigational Cancer Therapeutics, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Michael Geoffrey WhiteThe Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Michael J OvermanGastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA.ORCID http://orcid.org/0000-0001-5377-135X
Scott KopetzGastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA.
John Paul ShenGastrointestinal Medical Oncology, University of Texas System, Houston, Texas, USA JShen8@mdanderson.org.ORCID http://orcid.org/0000-0003-4588-2775

Funding

Protocol Review and Monitoring SystemP30CA016672 · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1985 to 2025
$57.3M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundOnly a subset of polymerase epsilon (

methodsThis retrospective cohort study included a pan-cancer cohort of 69,223 patients from cBioPortal and a cohort of patients with 41

resultsIn the pan-cancer cBioPortal cohort (n=69,223)

conclusionsIdentifying the subset of

Indexed as

DNA Polymerase IIImmunotherapyNeoplasmsPoly-ADP-Ribose Binding ProteinsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedMutationPrognosisRetrospective StudiesDNA Polymerase IIPOLE protein, humanPoly-ADP-Ribose Binding ProteinsBiomarkerColon CancerImmune Checkpoint Inhibitor

Identifiers

PMID41253491
PMCPMC12636876

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.