ArticleNPJ science of food2025
Stachyose attenuates DSS-induced colitis and is associated with elevated colonic medium-chain fatty acids: an integrated multi-omics analysis.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Stemness-associated MEF-derived extruded nanovesicles cooperate withNanoscale advances · 2026Article
- Stachyose supplementation attenuates ischemic stroke injury via gut-brain axis mediated adenine metabolism and neuroactive ligand-receptor signaling.Current research in food science · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation, immune dysregulation, and gut microbiota dysbiosis. Using a dextran sulfate sodium (DSS) mouse model, we applied an integrated multi-omics approach comprising untargeted metabolomics, colonic transcriptomics, and 16S rRNA sequencing to evaluate the effects of the prebiotic stachyose (STA). STA supplementation alleviated colitis and coincided with marked increases in several medium-chain fatty acids (MCFAs), including azelaic acid and 3-hydroxyoctanoic acid. Transcriptomic profiling revealed modulation of fatty acid metabolism genes (e.g., Mfsd2a, Anxa1) and enrichment of pathways such as PPAR signaling and fatty acid degradation. Microbiota analyses showed enrichment of Ruminiclostridium_9, Roseburia, and Christensenellaceae, with partial restoration of microbial diversity and functions. Integrated correlations linked specific taxa, MCFAs, and host lipid-related genes. While associative and requiring mechanistic validation, these findings suggest colonic MCFAs as candidate mediators of the protective effects of STA in experimental colitis.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.