Evidence map›Paper›PMID 41253987›Full record

ArticleScientific reports2025

Brain metabolic alterations in individuals with chronic non-specific neck pain assessed using proton magnetic resonance spectroscopy.

Rungtawan Chaikla, Suchart Kothan, Marco Barbero, Deborah Falla, Munlika Sremakaew, Sureeporn Uthaikhup

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rungtawan ChaiklaDepartment of Physical Therapy, Integrated Neuro-Musculoskeletal, Chronic Disease, and Aging Research Engagement Center (ICARE), Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Suchart KothanCenter of Radiation Research and Medical Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Marco BarberoDepartment of Business Economics, Health and Social Care, Rehabilitation Research Laboratory 2rLab, University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland.
Deborah FallaCentre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Munlika SremakaewDepartment of Physical Therapy, Integrated Neuro-Musculoskeletal, Chronic Disease, and Aging Research Engagement Center (ICARE), Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Sureeporn UthaikhupDepartment of Physical Therapy, Integrated Neuro-Musculoskeletal, Chronic Disease, and Aging Research Engagement Center (ICARE), Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand. sureeporn.uthaikhup@cmu.ac.th.ORCID http://orcid.org/0000-0002-5012-4437

Funding

Fundamental Fund (FF), Chiang Mai University FRB650031/0162 and FRB660046/0162
6 · The paper itself

Abstract

Altered brain metabolites in pain-related regions provide insights into the underlying mechanisms of chronic pain. However, brain metabolites alterations in chronic non-specific neck pain remain unknown. This study aimed to investigate brain metabolite concentrations in individuals with chronic non-specific neck pain and their relationships with pain-related outcomes. Participants included 30 individuals with chronic non-specific neck pain and 30 pain-free controls. Absolute concentrations and metabolite ratios of total creatine (tCr), choline (Cho), myo-inositol (mI), N-acetylaspartate (NAA) and glutamate/glutamine (Glx) were measured in regions involved in pain processing and modulation, including dorsolateral prefrontal cortex (DLPFC), primary somatosensory cortex (S1), insula and thalamus, using proton magnetic resonance spectroscopy (

Indexed as

BrainChronic PainNeck PainProton Magnetic Resonance SpectroscopyAdultAspartic AcidCholineCreatineFemaleGlutamic AcidGlutamineHumansInositolMaleMiddle AgedAspartic AcidCholineCreatineGlutamic AcidGlutamineInositolN-acetylaspartateBrain metabolitesChronic painMagnetic resonance spectroscopyNeck painNon-communicable diseases (NCDs)Pain outcomes

Identifiers

PMID41253987
PMCPMC12627812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.