Evidence map›Paper›PMID 41254156›Full record

ArticleScientific reports2025

HHQG ameliorates acute liver injury (ALI) by inhibiting NLRP3 activation through RASD1-mediated regulation of the PKCδ-NF-κB signaling pathway.

Chunli Ma, Linghong Wang, Lili Cao, Linyun Zhao, Xin Zhang, Chengyou Ma, Hua Lian, Xiufang Bao, Mutu Eerde, Qiqige Buren and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chunli Ma *School of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Linghong Wang *School of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Lili Cao *School of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Linyun ZhaoSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Xin ZhangSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Chengyou MaCollege of Geo-Exploration Science and Technology, Jilin University, Changchun, 130026, Jilin, China.
Hua LianCollege of Mongolian Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Xiufang BaoCollege of Mongolian Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Mutu EerdeMedical Innovation Center for Nationalities, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Qiqige BurenSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
He TongSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Lili DaiCollege of Mongolian Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China.
Guleng AmuInternational Mongolian Hospital of Inner Mongolia, Hohhot, 010065, Inner Mongolia, China.
Yulong BaoSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China. yulongbao@immu.edu.cn.
Mei HongSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China. hongmei060@126.com.
Li WangSchool of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, China. liwang0472@163.com.

Funding

Inner Mongolia Medical University 2025 Maker Cultivation Project 101322025138; 101322025102Innovative Research Team in Universities of lnner Mongolia Autonomous Region NMGIRT2418Project of Mongolian Medicine Collaborative Innovation Center, Inner Mongolia Autonomous Region MYYXTPY202401Science and Technology Plan of the Inner Mongolia Automous Region 2021GG0098Science and technology project of public hospital Research Union Fund 2024GLLH0148the Duxue Talent Program of Inner Mongolia Medical University ZY20243102the first-class discipline research project YLXKZX-NYD-009the general project of Inner Mongolia Medical University YKD2022MS006, YKD2021MS043, and YKD2024MS007The Inner Mongolia Medical University Doctoral Fund Start-up Project YKD2024BSQD022the key project of Inner Mongolia Medical University YKD2022ZD008the Natural Science Foundation of Inner Mongolia 2021MS08029, 2024MS08054, and 2024LHMS08024the Shanxue Talent Program of Inner Mongolia Medical University ZY20242109Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region NJYT23052
6 · The paper itself

Abstract

Acute liver injury (ALI) is a prevalent hepatic condition that poses significant risks to both life and overall health. Traditional Mongolian medicine utilizes Honghua Qinggan Thirteen-Flavor Pills (HHQG) as a primary formula for dispelling liver heat, illustrating both an extensive application in clinical settings and notable therapeutic effectiveness for treating liver ailments such as hepatitis and liver failure. Nevertheless, the molecular mechanisms underpinning the hepatoprotective properties of HHQG remain inadequately understood.We employed a CCl

Indexed as

Chemical and Drug Induced Liver InjuryDrugs, Chinese HerbalNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinProtein Kinase C-deltaSignal TransductionAnimalsCarbon TetrachlorideDisease Models, AnimalHumansInflammasomesLiverMaleMiceMice, Inbred C57BLMolecular Docking SimulationCarbon TetrachlorideDrugs, Chinese HerbalInflammasomesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseProtein Kinase C-deltaAcute liver injuryNetwork pharmacologyNLRP3 inflammasomeRASD1Traditional mongolian medicine

Identifiers

PMID41254156
PMCPMC12627768

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.