Evidence map›Paper›PMID 41254263›Full record

ReviewGeroScience2025

Redefining the concept of erythrocyte senescence: is eryptosis fundamentally different from erythrocyte senescence.

Anton Tkachenko, Ondrej Havranek, Florian Lang, Karl S Lang, Thomas Wieder

Abstract readReview
PubMed Publisher
In one paragraph

Review in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anton TkachenkoBIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 25250, Vestec, Czech Republic. anton.tkachenko@lf1.cuni.cz.ORCID http://orcid.org/0000-0002-1029-1636
Ondrej HavranekBIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 25250, Vestec, Czech Republic.
Florian LangInstitute of Physiology I, Eberhard Karls University Tübingen, Wilhelmstr. 56, 72074, Tübingen, Germany.
Karl S LangInstitute of Immunology, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Thomas WiederInstitute of Physiology I, Eberhard Karls University Tübingen, Wilhelmstr. 56, 72074, Tübingen, Germany.

Funding

European Hematology Association the EHA Ukraine Bridge FundingUniverzita Karlova v Praze by MEYSCRUniverzita Karlova v Praze Next Generation EUUniverzita Karlova v Praze Programme EXCELES
6 · The paper itself

Abstract

In response to acute stress, nucleated cells undergo various regulated cell deaths (RCDs). Alternatively and in the long run, they permanently stop proliferating with the parallel acquisition of apoptosis resistance and the senescence-associated secretory phenotype. This particular long-term stress response is referred to as cellular senescence. Terminally differentiated, anucleate red blood cells (RBCs) cannot proliferate anymore and are incapable of synthesizing proteins. RBC senescence is therefore defined by phagocytosis-promoting age-related changes, such as band 3 protein-derived senescent erythrocyte-specific antigen (SESA)-mediated binding of autologous antibodies, desialylated glycoproteins, CD47 loss, and glycophorin depletion. Additionally, RBCs can undergo eryptosis, a Ca

Indexed as

EryptosisPhosphatidylserine exposureRed blood cellsRegulated cell deathSenescence

Identifiers

PMID41254263

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.