Evidence map›Paper›PMID 41254265›Full record

ArticleScientific reports2025

Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies.

Linda P Siziba, Marko Mank, Bernd Stahl, Hermann Brenner, John Gonsalves, Bernadet Blijenberg, Katrin Horn, Markus Scholz, Parastoo Kheiroddin, Michael Kabesch and 3 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors.

Linda P SizibaPediatric Epidemiology, Department of Paediatrics, Medical Faculty, Leipzig University, 04103, Leipzig, Germany. Linda.Siziba@medizin.uni-leipzig.de.
Marko MankDanone Research & Innovation, Utrecht, 3584, The Netherlands.
Bernd StahlDanone Research & Innovation, Utrecht, 3584, The Netherlands.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.
John GonsalvesDanone Research & Innovation, Utrecht, 3584, The Netherlands.
Bernadet BlijenbergDanone Research & Innovation, Utrecht, 3584, The Netherlands.
Katrin HornInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, 04107, Leipzig, Saxony, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, 04107, Leipzig, Saxony, Germany.
Parastoo KheiroddinDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), University of Regensburg and The Order of St. John at the St. Hedwig Hospital, Regensburg, Germany.
Michael KabeschDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), University of Regensburg and The Order of St. John at the St. Hedwig Hospital, Regensburg, Germany.
Deborah WerneckeInstitute of Epidemiology and Medical Biometry, Ulm University, 89075, Ulm, Germany.
Dietrich RothenbacherInstitute of Epidemiology and Medical Biometry, Ulm University, 89075, Ulm, Germany.
Jon GenuneitPediatric Epidemiology, Department of Paediatrics, Medical Faculty, Leipzig University, 04103, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of maternal secretor status and child fucosyltransferase (FUT2) polymorphisms on respiratory and ear infections, and growth, is an emerging research area. But, the impact of discordant secretor status between mother and infant, where their secretor status differs, remains underexplored. This study investigated how infant FUT2 single nucleotide polymorphisms (SNPs) modify the association between maternal secretor/non-secretor milk phenotypes and child outcomes such as infections, and growth during the first two years of life in discordant mother-infant pairs. Data from n = 539 mother-infant pairs in the Ulm SPATZ Health Study (SPATZ) and n = 488 pairs in the Ulm Birth Cohort Study (UBCS) were analysed using logistic, modified Poisson, and linear regression models. A significant proportion of infants in both cohorts were heterozygous secretors (46% in SPATZ and 45% in UBCS), and about a third had discordant secretor status with their mothers. Non-secretor infants receiving secretor milk in SPATZ showed a significant increase in BMI between week 4/5 and month 3/4 compared to secretor infants. But these associations were not significant after adjusting for confounders and correcting for multiple testing (α threshold = 0.0035). Despite the non-significant results, the findings emphasize the need for further research on discordant secretor status and its health implications.

Indexed as

FucosyltransferasesMilk, HumanPolymorphism, Single NucleotideAdultBirth CohortCohort StudiesFemaleGalactoside 2-alpha-L-fucosyltransferaseHumansInfantInfant, NewbornMaleMothersFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseBody mass index (BMI)Fucosyltransferase (FUT2)Lower respiratory tract infections (LRTI)Non-secretor milkOtitis media (OM)Secretor milkSingle nucleotide polymorphisms (SNPs)Upper respiratory tract infections (URTI)

Identifiers

PMID41254265
PMCPMC12627658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.