ReviewStem cell research & therapy2025
Harnessing engineered mesenchymal stem cell-derived extracellular vesicles for innovative cancer treatments.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Stem cell-based therapies in pediatric disorders: translational advances, unresolved challenges, and future horizons.Stem cell research & therapy · 2026Review
- Storage-associated physicochemical changes in extracellular vesicles derived from human mesenchymal stromal cells.Frontiers in bioengineering and biotechnology · 2026Article
- The Evolving Role of Mesenchymal Stem Cells and Their Exosomes in Epilepsy Management: From Bench to Bedside.Stem cells international · 2026Review
- Lipid nanoparticles and extracellular vesicles: emerging cell free therapeutic platforms for hepatobiliary cancers.Frontiers in cell and developmental biology · 2026Review
- Mesenchymal Stromal/Stem Cells (MSCs) in Cancer Therapy: Advanced Therapeutic Strategies Towards Future Clinical Translation.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Mesenchymal stem/stromal cells (MSCs) are known for their regenerative and immunomodulatory capabilities, which have made them the focus of extensive therapeutic research. A growing body of evidence underscores that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising cell-free platform that mimics the therapeutic benefits of MSCs while mitigating their associated risks. This review synthesizes recent advancements in bioengineering strategies aimed at enhancing the therapeutic efficacy, targeting specificity, and cargo-loading capacity of MSC-EVs for cancer treatment. These strategies include endogenous and exogenous modification approaches. Endogenous strategies involve genetically modifying parental MSCs or using environmental preconditioning to modulate the extracellular vesicles (EVs) content or surface proteins of EVs they produce. Exogenous techniques include post-isolation loading of therapeutic cargo, such as small interfering RNAs (siRNAs) and microRNAs (miRNAs), as well as EV membrane modifications. We also highlight key preclinical and clinical findings, addressing the dual role of MSC-EVs, which can be either pro- or anti-tumorigenic depending on the MSC tissue origin and the tumor microenvironment. Notably, EVs derived from human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) show the most consistent tumor-suppressive activity, making them a preferred choice for clinical development. Despite challenges related to production scalability, cargo-loading efficiency, and regulatory standardization, engineered MSC-EVs are poised to become a transformative platform in next-generation, cell-free precision cancer therapies. Future efforts, including the establishment of protocols compliant with Good Manufacturing Practice (GMP) and the integration of engineering advancements, will be essential for advancing healthcare innovations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.