ReviewJournal of neurochemistry2025
Whispering Through the Barrier: Signaling Interfaces for Peripheral Regulation of Brain Function in Obesity.
Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lipid Metabolic Disorders: a Pivotal Driver in Type 2 Diabetes Mellitus Pathogenesis.Current obesity reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review highlights signaling modalities at the blood-brain and blood-cerebrospinal fluid barriers, with reference to the cell types and pathways recruited under steady state conditions and in obesity. We summarize areas of consensus and unresolved questions surrounding the temporal progression of neuroinflammation and the propagation of neuroimmune responses between different cell types and circuits. While data on the reversibility of these changes is scarce, we review the available data on reinstatement of neuroimmune homeostasis following physiological and pharmacological interventions. Published data from preclinical models aligns with evidence implicating middle age as a critical period for the impact of obesity on brain function in humans. Elucidating the metabolic and immune signatures associated with neurological dysfunction could identify novel biomarkers and inform the development of targeted strategies to improve healthspan in obese individuals.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.