Evidence map›Paper›PMID 41255282›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Biodegradable Adhesive Systems for Bio-Integrated Applications.

Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li-Hyun Kim, Venkata Ramesh Naganaboina, Suk-Won Hwang

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Won Bae HanKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.ORCID https://orcid.org/0000-0002-4855-9562
Sungkeun HanKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Prashant Shivaji ShewaleKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Hyewon ChoKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Li-Hyun KimKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Venkata Ramesh NaganaboinaDepartment of Electronics and Communication Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Amaravati Campus, Amaravati, Andhra Pradesh, 522503, India.
Suk-Won HwangKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.ORCID https://orcid.org/0000-0002-6883-201X

Funding

Korea government (the Ministry of Science, ICT, MSIT) IITP-2025-2020-0-01819Korea government (the Ministry of Science, ICT, MSIT) RS-2022-00165524Korea government (the Ministry of Science, ICT, MSIT) RS-2023-00220534Korea Institute of Science and Technology 2E32501-23-106
6 · The paper itself

Abstract

Biodegradable adhesives, unlike their traditional counterparts, are engineered to bond to biological tissues while naturally degraded over time, thereby eliminating the need for removal procedures and reducing the risk of chronic inflammation. These unique features are particularly suitable for temporary biomedical applications such as wound closure, internal sealing, or integration with electronics for active/passive functions. The adhesive performance arises from the strategic combination of biodegradable polymers and adhesion mechanisms that dynamically interact with tissue surfaces. This review introduces recent advancements in biodegradable adhesives through a mechanism-based framework, focusing on five key adhesion strategies: physical interlocking, hydrogen bonding, catechol chemistry, amine-carboxyl coupling, and covalent bonding via diazirine or isocyanate linkages. For each strategy, representative material systems, functional properties, and biomedical implementations that enable strong, conformal adhesion under wet and physiological environments are highlighted, and with a discussion of current challenges and future directions toward intelligent, multifunctional bioadhesives for clinical uses are concluded.

Indexed as

AdhesivesBiocompatible MaterialsPolymersTissue AdhesivesAnimalsHumansAdhesivesBiocompatible MaterialsPolymersTissue Adhesivesadhesivesbiodegradablebioelectronicsbiomedical applicationswound closure

Identifiers

PMID41255282
PMCPMC13042945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.