Evidence map›Paper›PMID 41255284›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.

Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun Goo RoSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID https://orcid.org/0000-0002-7023-086X
Yoojin ChangSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Jeeyoon KimSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Seungjae LeeSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID https://orcid.org/0000-0002-4879-6357
Sangyun NaSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Cheolhong ParkSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID https://orcid.org/0000-0001-8992-6317
Hyunhyub KoSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID https://orcid.org/0000-0003-2111-6101

Funding

National Research Foundation (NRF) of Korea RS-2021-NR059784National Research Foundation (NRF) of Korea RS-2022-NR068144National Research Foundation (NRF) of Korea RS-2024-00410962
6 · The paper itself

Abstract

Iontronic bioelectronics provides a powerful framework for bridging the mismatch between conventional electronic systems and soft, ion-mediated biological tissues. By harnessing mobile ions as charge carriers and functional mediators, iontronic devices enable biocompatible, conformal, and low-impedance interfaces that support both signal acquisition and therapeutic delivery. Recent advances in ionic materials, such as hydrogels, ion gels, and ionic liquids, have facilitated high-fidelity physiological sensing, wound monitoring, and programmable drug and ion release. In addition to passive sensing and delivery, emerging iontronic platforms integrate real-time biosignal monitoring with adaptive, AI-guided feedback to enable closed-loop therapeutic control. This review highlights the multifunctional role of ions in sensing, modulation, and stimulation across diverse applications, including skin-interfaced electronics, neural and cardiac interfaces, and wound therapy. Key challenges such as operational stability, signal specificity, and long-term biocompatibility are further examined, and material, structural, and system-level innovations that are paving the way toward intelligent, responsive, and clinically viable iontronic bioelectronic platforms are discussed.

Indexed as

BionicsBiosensing TechniquesIonsAnimalsHumansIonsbioelectronic interfacebiosensingIonic materialsiontronicstherapeuticstissue interfacing

Identifiers

PMID41255284
PMCPMC13042800

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.