SynthesisFrontiers in endocrinology2025
Association of hypertensive disorders of pregnancy with offspring cardiometabolic indicators: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertensive disorders of pregnancy (HDP) are a major public health problem affecting a large number of pregnancies worldwide. Despite extensive research, little is known about the long-term cardiometabolic consequences of HDP exposure in offspring. Objective: To investigate the long-term cardiometabolic risks in offspring exposed to HDP. Search strategy: A comprehensive search of relevant studies published in PubMed, EMBASE, the Cochrane Central Register, and Web of Science databases was conducted. Selection criteria: Inclusion criteria comprised case-control and cohort studies, with outcome measures encompassing blood pressure, body mass index, lipid levels, and glucose metabolism. Data collection and analysis: Meta-analysis was performed using Review Manager 5.4, and fixed- or random-effects models were selected as appropriate. Main results: A total of 23 observational studies with 89,982 participants from 10 countries were included. Meta-analysis indicated that offspring exposed to HDP presented with significantly increased systolic blood pressure (MD: 2.44; 95% CI: 2.03-2.85; Conclusions: The impact of HDP on offspring cardiometabolism is multifaceted. Elevated blood pressure and body mass index are more likely to be observed in offspring exposed to HDP, while the risk of insulin resistance appears to be reduced. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025630378, identifier CRD42025630378.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.