ReviewJuntendo medical journal2025
Is Antithrombin Supplementation Effective in Suppressing ECMO Circuit Thrombosis in Sepsis?
Review in Juntendo medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracorporeal membrane oxygenation (ECMO) is increasingly used for the management of severe sepsis-induced cardiopulmonary failure. Despite standard heparin anticoagulation, circuit thrombosis remains a significant complication. Antithrombin (AT), a critical serine protease inhibitor and cofactor for heparin, is often low in septic patients, especially during ECMO, raising concerns about the efficacy of heparin-based anticoagulation. This review explores the role of AT supplementation to suppress ECMO circuit thrombosis in sepsis, integrating epidemiological data, underlying pathophysiology, preclinical research, and clinical evidence. While theoretical rationale and some observational data support the supplementation of AT, definitive clinical trials are lacking. We conclude by outlining future perspectives and research needs to clarify the role of AT in ECMO management for septic patients.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.