ArticleJournal of inflammation research2025
Abnormal Alterations in EEG Microstates and Functional Networks in Anti-LGI1 Antibody Encephalitis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Objective: This study aimed to use electroencephalogram (EEG) microstate analysis to characterize transient topographic patterns and rapid brain network reorganization in anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis (anti-LGI1-AE). Methods: EEG data were collected from fifteen patients with anti-LGI1-AE and eighteen age- and sex-matched controls. K-means clustering was used to extract microstate sequences, and temporal parameters were compared between groups. For microstates showing significant differences, weighted phase lag index matrices were computed across frequency bands, and network-based statistics were applied to identify functional connectivity differences. Results: The topographic pattern of Microstate A differed significantly between the anti-LGI1-AE group and the control group ( Conclusion: Widespread alterations in functional brain networks are present in anti-LGI1-AE. Changes in microstate temporal parameters and enhanced functional connectivity may reflect compensatory regulatory mechanisms or pathological hyperactivation, revealing functional brain changes that go beyond overt structural damage.
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