ArticleFrontiers in medicine2025
Diagnostic study of serum claudin-3 and zonulin for intestinal barrier dysfunction after abdominal surgery.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Role of gut microbiota in melanosis coli: from anthraquinone biotransformation to mucosal homeostasis dysbiosis.Frontiers in pharmacology · 2026Review
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7 authors.
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Abstract
Background: Previous studies have shown that serum claudin-3 and zonulin play important roles in reflecting intestinal barrier function. This study aims to explore the diagnostic value of serum claudin-3 and zonulin in assessing intestinal barrier dysfunction following abdominal surgery. Methods: A rat model of intestinal ischemia-reperfusion (I/R) injury was established, and hematoxylin and eosin (HE) staining was performed to observe the damage to the intestinal mucosa. Pearson correlation analysis was conducted to assess the relationship between changes in serum claudin-3 and zonulin concentrations and the degree of intestinal mucosal injury. Subsequently, patients undergoing abdominal surgery were included in the clinical study to measure the levels of claudin-3 and zonulin in the blood; peripheral blood Results: The degree of intestinal mucosal injury in rats and the concentrations of serum claudin-3 and zonulin both exhibited a trend of initially worsening and then improving, peaking at 24 h post-reperfusion. The changes in serum claudin-3 and zonulin concentrations were significantly positively correlated with the degree of intestinal mucosal tissue injury. In patients with intestinal barrier dysfunction, the copy number of Conclusion: Following intestinal mucosal injury, the greater the degree of damage, the higher the concentrations of serum claudin-3 and zonulin, which are positively correlated, peaking at 24 h post-operation. Serum claudin-3 and zonulin have good predictive value for postoperative intestinal barrier dysfunction, with serum claudin-3 demonstrating a higher diagnostic value than serum zonulin for postoperative intestinal barrier dysfunction.
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