ArticleMediators of inflammation2025
Nonlinear Association Between the C-Reactive Protein-Triglyceride-Glucose Index and Rheumatoid Arthritis Risk: The Mediating Role of Body Mass Index.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Clinical Significance of the C-Reactive Protein-Triglyceride-Glucose Index in Cardiovascular Disease, Stroke, Cardiovascular-Kidney-Metabolic Syndrome, Cancer, Diabetes, and Osteoporosis: A Narrative Review.International journal of general medicine · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Rheumatoid arthritis (RA) is a growing public health concern with rising incidence worldwide. The C-reactive protein-triglyceride-glucose index (CTI), a composite marker of inflammation and insulin resistance, has been linked to various metabolic disorders, but its role in RA remains unclear. This study aimed to examine the association between CTI and RA risk and assess whether body mass index (BMI) mediates this relationship. Methods: We analyzed data from 4292 participants using the 2005-2010 National Health and Nutrition Examination Survey (NHANES). CTI was computed and stratified into quartiles. Multivariable logistic regression models assessed the association between CTI and RA after adjusting for demographic, socioeconomic, lifestyle, and clinical confounders. Restricted cubic spline (RCS) functions were employed to test for nonlinear patterns. Additionally, subgroup analyses examined effect modification, and mediation analysis quantified the indirect effect through BMI. Results: Elevated CTI values were independently linked to higher odds of RA. After full adjustment, each one-unit rise in CTI corresponded to a 45% increase in RA odds (OR = 1.45, 95% CI: 1.22-1.73, Conclusions: CTI is nonlinearly and independently associated with RA risk, partly through BMI, highlighting its potential as a biomarker linking metabolic and inflammatory pathways.
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Registered trials
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